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HiChIP is changing cancer research

Enhancer hijacking drives oncogenic BCL11B expression in lineage ambiguous leukemia

SPEAKER: Dr. Lindsey Montefiori

About the Webinar

  • A rare disease with diagnostic challenges. A new subtype of acute leukemia defined by structural variants (SVs) targeting the T-cell transcription factor BCL11B has been identified
  • Using HiChIP to dive into the mechanisms. H3K27ac HiChIP demonstrates these SVs result in aberrant interactions between the BCL11B gene/promoter and hematopoietic progenitor cell super enhancers, or de novo super enhancers generated through a high copy tandem amplification event downstream of BCL11B
  • Chromatin structure reflects genomic alterations. BCL11B overexpression in human hematopoietic progenitor cells results in lineage skewing, supporting a role for ectopic BCL11B expression in driving lineage ambiguous leukemia

About the Speaker

Dr.Lindsey Montefiori

Dr. Lindsey Montefiori

Postdoctoral Fellow at St. Jude Children’s Research Hospital

Dr. Montefiori received her PhD from the University of Chicago in the Nobrega Lab of the Department of Human Genetics, where she used promoter capture Hi-C to map cardiovascular disease GWAS loci to target genes. She is currently a postdoctoral fellow in the Charles Mullighan lab at St. Jude Children’s Research Hospital, Department of Pathology. Dr. Montefiori is focused on modeling genomic alterations in lineage ambiguous leukemia.